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For recycling, cells were incubated with agonists at 37 C for 15 min, followed by endocytosis arrest at 4 C, surface label removal as above, 30 min incubation at 37 C with 10 M exendin(9-39) to prevent further internalization, and a second round of surface label removal at 4 C

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Julius, D

These developments may contribute to future claims alleging inadequate warnings, insufficient dosing instructions, or failure to address foreseeable risks tied to widespread consumer use

Retatrutide also brings attention to the broader field of multi-receptor agonists