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Missing a dose or administering it at a different time each day can disrupt the protocol

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Proper storage directly affects both safety and potency
The 2014 paper by Benoist et al

Combined analysis of mifepristone for psychotic depression: plasma levels associated with clinical response
according to the National Academies of Sciences, Engineering, and Medicine, absorption is approximately 50% at 1 mcg but falls to roughly 1.3% at 1,000 mcg