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These findings indicate a protective role of CoQ against the toxicity of PUFA oxidation, which is further supported by the observation that the sensitivity of coq3 yeast to Lnn can be reduced by vitamin E and the antioxidant butylated hydroxytoluene (BHT) (331, 332)

Signaling impairments within the glutamatergic and cholinergic systems are the main targets of currently approved AD therapies (Parsons et al., 2013)

J Agric Food Chem 67:51135121

The leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that coordinates a variety of cellular processes, including vesicle transport, autophagy, lysosomal degradation, neurotransmission and mitochondrial activity (Zhu et al., 2023

doi: 10.1016/S0022-2828(08)80021-1

Extracellular collagen, in the absence of enzymatic degradation by MMPs, has a longevity that dwarfs the average human life expectancy due to its dense helical structure and resistance to proteolysis
