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Increased irregularities in blood flow patterns result in elevated levels of disturbed shear stress [12]

They also showed that while p53 abnormalities had only affected one allele in typical CLL, 4 out of 7 CLL/PLL cases had both alleles inactivated, implying a correlation between the accumulation of p53 abnormalities and CLL/PLL developments [458]

Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig

(Berlin: Walter de Gruyter GmbH), 2141

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[DOI] [PubMed] [Google Scholar] 234.Allan A.M., Baier L.D., Zhang X