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These emerging concepts underscore the need to broaden the mechanistic framework of cardioprotection to include the vasculature and the immune system, encompassing both innate and adaptive responses [8, 33]

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However, a much repeated criticism of studies of MSG taken without food is that the characteristic strong flavor of MSG is difficult to mask, unblinding the subjects to its identity and potentially leading to bias. Even in people who self-identify as MSG sensitive, studies have failed to provide reproducible evidence of an MSG effect. The authors of the largest and most comprehensive of such studies concluded that large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG

Some people receive IV therapy a few times per year during travel or intense work periods

Syst Appl Microbiol 44:126222