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Intracerebroventricular and intraparenchymal routes may provide effective delivery of small and large molecule therapies for preclinical neuroprotection studies

Durch toxische Einflsse wird das Gleichgewicht zum oxidierten Status (GSSG) verschoben

A crucial role is played by endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) that act on O 2 and H 2 O 2 , respectively, as well as glutathione peroxidase (Gpx) that uses GSH as co-substrate (Fu and Chung 2018)

Factors like hyperoxia, oxidative stress, and inflammatory cytokines induce SOD2, whereas SOD3 are cell and tissue-specific and likely of significant importance in protection against stress factors from the extracellular environment

Clinical randomized controlled trials have begun to investigate the effects of GSH supplementation on MASLD/MASH

doi: 10.1016/j.bbalip.2019.03.003