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doi: 10.1182/blood-2017-04-779769 136 MerliPPagliaraDGalavernaFLi PiraGAndreaniMLeoneGet al
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In dogs, the dose-limiting toxicity of vinblastine is characterized by neutropenia, with its nadir occurring approximately 7 days after administration [201,202,203,204,205]

However, RNAi therapeutics still face technical obstacles, such as achieving efficient delivery of RNAi drugs targeting organs or tissues and overcoming the off-target interactions (Persengiev et al., 2004

Particularly, more c-Met gene amplifications can be found in patients with metastatic liver cancer (Zeng et al., 2008)

For example, Xi et al
