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Purpose To investigate the integrated therapeutic benefits of the phytopharmaceutical berberine and mucoadhesive nanoliposomes, administered via the nose-to-brain route, to enhance bioavailability, facilitate blood-brain barrier penetration, and augment efficacy against neurodegenerative progression in Parkinsons disease (PD)

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The study also explores the AITC and protein-protein interaction among pepsin and mustard seed proteins, cruciferin and napin, as mustard contains abundant protein content but remains bio-unavailable due to presence of similar anti-nutritional factors like glucosinolates potentially having insect deterring potential

and mild allergic reactions like itching