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Understanding how pharmacological and microbiota-targeted interventions converge on shared signaling pathways may therefore be critical for identifying biomarkers of treatment response and developing more effective, mechanism-based therapeutic strategies

BakkerPButterLKorsLTeskeGAtenJSutterwalaFet alNlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

10.1016/0005-2760(83)90047-4 125 MarcusD

[DOI] [PubMed] [Google Scholar] 273.Bohdjalian A., Langer F.B., Shakeri-Leidenmuhler S., Gfrerer L., Ludvik B., Zacherl J

Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response

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