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Furthermore, Bui et al (71) demonstrated that treatment of intestinal epithelial cells or hepatocytes with SCFAs, particularly butyrate, notably upregulated the expression and activity of 17-hydroxysteroid dehydrogenase and 3-hydroxysteroid dehydrogenase

In other words, the standard tools your prescribing physician relies on to assess the efficacy of opioids will fail to show any benefits

PMID: 32819881

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Drummond, A

This author had a history of HT-associated subclinical hypothyroidism, which she monitored with periodical checks of serum thyroid function tests and thyroid autoantibodies