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In an ischemic mouse model, lactate was shown to trigger astrogliosis through the activation of Akt and STAT3 signaling pathways, further linking metabolic shifts to astrocyte reactivity 78

Ann Allergy Asthma Immunol 96(3):497500

Retrieved November 12, 2022

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These include downregulation of sGC and upregulation of phosphodiesterase activity
