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Many oral treatments have been studied, but results so far have been mixed.[5] Some consider the use of non-surgical approaches to be "controversial".[6] Vitamin E supplementation has been studied for decades, and some success has been reported in older trials, but those successes have not been reliably repeated in larger, newer studies.[7] A combination of Vitamin E and colchicine has shown some promise in delaying progression of the condition.[8] Newer agents targeting the basic mechanisms of inflammation have not yet been studied in larger clinical trials

49 Palmitoylethanolamide

TMA is transported to the liver and oxidized into TMAO by the liver enzyme FMO3 (Wang et al

[304] first investigated the effect of treatment-related improvements in cognitive function on HRQoL