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Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

The predicted model of napin and cruciferin, acting as a ligand, was docked with Pepsin, the receptor protein

10.1073/pnas.1110085108 16 BrownG

M.CruzatV.et al (2016)

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Similarly, the spatial distinction is seen in macrophages: endogenous ROS, potentially originating from mitochondrial Lon protease, reinforces the immunosuppressive M2 phenotype, whereas exogenous ROS bursts, often iron-dependent, can forcibly repolarize macrophages to the anti-tumor M1 phenotype