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For non-hematological AEs using multivariate logistic regression analysis, the C/T genotype group of MTHFR_a , high serum RBP level before pemetrexed treatment, high serum B12 level before premedication, and high red blood cell (RBC) count before pemetrexed treatment (Supplementary Table S3(a)) were the crude low-risk factors for G2G4 non-hematological AEs in the first cycle

Important limitations you should know For people with normal B12 levels, the evidence is far less compelling

Hold upright, again with the blue needle at the top and gently push out any remaining air Step 13

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