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Research in 2022 concluded that high B12 in cancer patients is often an epiphenomenon

Bruckbauer et al

B12 Injections and Weight Loss The idea of B12 shots leading to weight loss probably came from the observational studies that linked low vitamin B12 to a higher body-weight: Low vitamin B12 level was associated with obesity and overweight, but not with insulin resistance, metabolic syndrome and gender

Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria

These include: Heartburn drugs and stomach-acid reducers like omeprazole (Prilosec) and ranitidine (Zantac) Metformin, a diabetes medication Vitamin C Anti-seizure medications like phenytoin (dilantin) Colchicine, a gout medication Bile acid sequestrants to lower cholesterol like colestipol (Colestid), cholestyramine (Questran), and colesevelam (Welchol) Tetracycline, an antibiotic

Benefits are still being researched, so claims stay measured