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doi:10.1016/j.bbagen.2013.04.016 2 Millea, P

In its severe forms, it results in the appearance of erythematous cysts (red and swollen lesions) or comedones (blackheads), replacing the smooth and homogeneous appearance of the skin with painful and visible imperfections

It is also essential to highlight that while higher levels of MET amplification tend to correlate with a better response to c-MET inhibitors, overall responses in MET amplified tumor are low, suggesting that wt c-MET may be a poor oncogenic driver even when overexpressed

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10.1002/msb.20145228 63 KhanS