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Since sleep regulates the brains clearance of metabolic toxins such as tau and A-42 peptides via the glymphatic system, age-related sleep disruption may impair this clearance, thereby exacerbating neuronal pathology through increased ROS production and ultimately triggering neuronal apoptosis (Xie et al., 2013

Moreover, the gut microbiota system and its metabolites can change the immuno-inflammatory state (93), which is indicated by the abnormal production of chemokines, cytokines and inflammatory markers (94)

It also modulates the release of glutamate, D-serine and ATP from astrocytes 99

Die parallele Studie REDEFINE 2 untersuchte die Kombination Cagrilintid + Semaglutid bei Erwachsenen mit Typ-2-Diabetes und dokumentierte eine signifikante Gewichtsreduktion sowie eine verbesserte Blutzuckerkontrolle

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Kuo et al., 1995)
