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Zhou W, Hu G, He J, Wang T, Zuo Y, Cao Y, et al

Additionally, Jones et al

Mutations in this pathway lead to uncontrolled growth and proliferation

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HO-1 is in charge of the oxidation of the heme groups free of ferrous iron (Fe2+), carbon monoxide, and biliverdin, the latter being reduced to bilirubin by biliverdin reductase, which acts as a fat-soluble antioxidant [32]
