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It is essential for the production of myelin, a protective layer around nerves that helps transmit signals efficiently in the brain

The effects of recombinant human IGF-I administration on concentrations of acid labile subunit, IGF binding protein-3, IGF-I, IGF-ii and proteolysis of IGF binding protein-3 in adolescents with insulin-dependent diabetes mellitus

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Investigations suggest it may bind to pituitary GHRH receptors, leading to cyclic AMPmediated signaling and downstream hormonal release in experimental systems

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