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Description
Microglia responses to pro-inflammatory stimuli (LPS, IFN+TNF) and reprogramming by resolving cytokines (IL-4, IL-10)

For example, melatonin can not only directly clean ROS but also promote antioxidant enzymes such as GPx and glutathione reductase, thereby indirectly scavenging ROS

It exhibits various biological activities, including mucoadhesive, antioxidant, and antitumor effects

PLoS One 11:e0148494 Tripathi A, Indoliya Y, Tiwari M, Tiwari P, Srivastava D, kumar Verma P, Verma S, Gautam N, Chakrabarty D (2014) Transformed yeast ( Schizosaccharomyces pombe ) overexpressing rice Tau class glutathione S-transferase (OsGSTU30 and OsGSTU41) shows enhanced resistance to hexavalent chromium

A critical appraisal of the protective activity of polyphenolic antioxidants against iatrogenic effects of anticancer chemotherapeutics
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This provides higher bioavailability
