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This is particularly true for pyruvate kinase, the terminal enzyme in glycolysis

There is also an elevation of serum FSH

pmid:15798895 18

Conversely, ABCC1 overexpression induces resistance to BCL-2 inhibitors by reducing intracellular drug levels, and high ABCC1 levels predicts poor response to Venetoclax therapy in patients

2020 Feb 18;11(1):941

[DOI] [PubMed] [Google Scholar] 225.Saw C.L., Huang M.T., Liu Y., Khor T.O., Conney A.H., Kong A.N
