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However, the inhibition of the 17-hydroxylase activity of CYP17, CYP11B1 and a panel of hepatic CYP enzymes leads to adverse effects and toxicities that include secondary mineralocorticoid excess

Because 5 mM Myo-Ins produced the strongest effects, we next examined its impact over longer exposure times (3.5 h to 48 h) in normal fibroblasts (Fig

Senescence-associated -galactosidase (SA--gal) activity was measured in both cells and frozen tissues using a commercial kit, providing a visual and quantitative indicator of senescent cells

To achieve liver-specific overexpression, the full-length murine PPAR complementary DNA (cDNA) with an mCherry tag was cloned into an adeno-associated virus 8 (AAV8) vector under the control of the thyroxine-binding globulin (TBG) promoter (VectorBuilder)