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T cell exhaustion is well documented in viral infections and various cancer settings and is hypothesized to arise at least in part due to chronic antigen stimulation, though the pathways leading to exhaustion, particularly in the cancer setting, remain incompletely defined (208)

Studies show it has multiple functions: regulating insulin sensitivity and metabolic homeostasis, preventing age- and high-fat diet-induced insulin resistance/obesity in mice, protecting the heart in cardiovascular diseases via relevant pathways, and reducing inflammation when intraperitoneally administered

Joe AK, Liu H, Suzui M, Vural ME, Xiao DWI (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines

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Glutathione is mainly involved in eliminating hydrogen peroxide (H 2 O 2 ) which is catalyzed by GSH peroxidase, thus preventing cellular lipid peroxidation (Fig