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Symptoms range from those of alcoholic hepatitis to the complications of end-stage liver disease, such as portal hypertension (often with esophageal varices and upper gastrointestinal bleeding, splenomegaly, ascites, and portosystemic encephalopathy)

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Additionally, high cortisol levels can interfere with insulin regulation, causing blood sugar imbalances that further drive sugar cravings

Oxidative stress, marked by increased ROS production and GSH consumption, is implicated in various neurodegenerative and neuropsychiatric disorders such as Parkinsons disease, Alzheimers disease, multiple sclerosis, and schizophrenia 4,5

Trx modulates NF-B activity and plays different roles extracellularly and intracellularly