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In the ATP-bound conformation, the mutation of Gly to Asp will have limited expected effects, resulting most probably in a rotamer rearrangement in respect of D999 with limited consequences on the backbone position

The gut microbiota can metabolize ellagitannins into urolithin metabolites through hydrolysis, reduction, and other reactions, while ellagitannins and their metabolites can also selectively regulate the composition of the microbiota (Sanchez-Terron et al., 2024)

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