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Preclinical research refers to early-stage studies conducted in laboratory settings using cell cultures or animal modelscommonly rodentsto explore biological mechanisms and generate hypotheses

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Copyright National Institutes of Health (NIH), 2025 Introduction G protein-coupled receptors (GPCRs) are cell surface receptors that receive and transmit signals from outside the cell, regulating a broad range of human physiological processes, making them a major target of pharmacological allosteric modulators

Psychiatry 87 , 871878 (2016)