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Cytokines and other TME components can activate survival signaling pathways, enabling tumor cells to resist chemotherapy and targeted therapies

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Decision: Focus on biosensors: Looking through the lens of quantitative biology R1/PR8 Comments No accompanying comment

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Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

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POGZ truncating alleles cause syndromic intellectual disability

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This review synthesizes recent advances in ferroptosis biology within AML, highlighting the unique metabolic vulnerabilities of leukemic cells, including dysregulated iron homeostasis, elevated reactive oxygen species (ROS), and cystine/glutamine dependencies, that create a ferroptotic trap. Despite promising preclinical outcomes, challenges such as biomarker validation, metabolic evasion, and nanoparticle delivery optimization persist

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Composite fillings, for example, are widely used biocompatible materials

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