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The macrocycle 23 was selected as a proper research tool for more detailed studies since the molecule is convenient to prepare and due to its structural similarity to the IRAP substrates oxytocin and vasopressin in its N-terminal

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Moreover, PPIs can disrupt the gastric acid barrier and intestinal microecology and cause exogenous bacterial invasion, which can lead to infectious diseases of the gastrointestinal and biliary tracts and SIBO