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This does not mean every patient will experience the same response

Thus the best known function of B-12 (that which is indirectly involved with DNA synthesis and restoration of cell-division and anemia) is actually a facultative function which is mediated by B-12 conservation of active folate which can be used for DNA production

First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design

10.1016/j.bcp.2019.02.008 96 NeelakantanH.VanceV.WetzelM

The ATTAIN-MAINTAIN trial also showed that patients can transition from injectable agents to orforglipron while maintaining their weight loss

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