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Cell 2002

In the clonal selection mechanism, it was found that a subpopulation of cells with drug-tolerance/resistance can be detected in patient cancer tissues prior to treatments

When GPX4 is inhibited or depleted, lipid peroxidation spirals out of control, leading to cell death ( - , which imports cystine for glutathione (GSH) synthesis, also plays a crucial role

Pharmacokinetic profiling during pregnancy has shown a decrease in C max values in maternal plasma during the second and third trimesters, although the cord blood/maternal plasma concentration ratio was 1.25, suggesting high placental transfer (Mulligan et al., 2018)

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