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As with other valproate products, doses of Depakote ER should be individualized and dose adjustment may be necessary

Exercise Performance: Some studies suggest that L-carnitine supplementation may improve exercise performance by enhancing fat utilization and reducing muscle fatigue

Liu T, Chi H, Chen J, Chen C, Huang Y, Xi H, Xue J, Si Y

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b., Lipoic acid metabolism and mitochondrial redox regulation

Even though there are concerns for the development of kidney disease in CPTII patients due to the high metabolic overload associated to rhabdomyolysis, end-stage chronic renal insufficiency requiring dialysis is only occasionally reported in these patients (Joshi and Zierz, 2020)