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Pregnenolone serves as the precursor for multiple different classes of steroid hormones, through divergent reactions that occur in both the mitochondria and ER

It helps keep red blood cells healthy and supports the nervous system

ETT is present on skin cells, allowing them to import ET and reduce levels of reactive oxygen species and DNA, protein, and lipid damage in keratinocytes subjected to solar-simulating UV oxidative stress (80)

It is considered that ototoxicity occurs through a multifactorial mechanism, involving oxidative stress 1

To test this directly, we performed hyperinsulinemic-euglycemic clamp studies (Supplemental Figure 1P)

Consistent results have been observed in both patients with depression and those with IBD (344346)