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Our review also identified that longitudinal studies, and studies assessing GSH levels in both brain and blood are lacking

Image acquiring was carried out using a Plan-APO 100/1.4 NA oil objective with the following filter set: BP 450488 nm, FT 495 nm, and BP 512542 nm

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Table 2 Disease-modifying treatments for mitochondrial diseases

Chelation therapy, including nonabsorbed agents, should be initiated at a low dose and then gradually titrated to recommended doses according to the individual's response, to avoid the patient's health deteriorating with metal redistribution, other physiological perturbations, or drug intolerance

The peptide diffuses slowly from the injection site into surrounding capillaries over 3090 minutes, creating sustained low-level serum exposure rather than the sharp peak seen with intravenous bolus