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Additionally, electrophysiological experiments have shown the direct effects of B vitamins on pain transmission pathways in the spinal cord and thalamus, which explains the observed reduction or loss of pain sensation in clinical patients

doi: 10.1111/jcpt.13464 46 BrandtR.TrushinaN

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Method for preparing in vivo formulation: Take L DMSO master liquid, next add L Corn oil, mix and clarify