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Specific abnormal clinical presentations require targeted interventions to mitigate their impact on daily functioning

A study found that the expression of PDL1 is up-regulated in the HCC cells of mice treated with c-Met inhibitors, which induces the functional inactivation of T-cells and enables HCC cells to escape from the killing of T-cells ( in vitro experiment of NSCLC (Sun et al., 2020)

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If PCAC recommends inclusion and the FDA agrees, the supply side becomes the next bottleneck

Sougiannis AT, VanderVeen BN, Davis JM, Fan D, Murphy EA
In: Chowdhury MEH, Kiranyaz S, editors
