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[176] Prolonged elevations of brain temperature above 40 C likely promote the development of amphetamine-induced neurotoxicity in laboratory animals by facilitating the production of reactive oxygen species, disrupting cellular protein function, and transiently increasing bloodbrain barrier permeability

Biochem Biophys Res Commun 318(1):8894

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They wait outside the mitochondria regardless of how much fat has been mobilized from adipose tissue into the bloodstream.

Obstet Gynecol 101:11771182 Archibong AE, Rideout ML, Harris KJ, Ramesh A (2018) Oxidative stress in reproductive toxicology

Hormonal changes can also be the cause
