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Views of aging and senescence frequently highlight a deterioration in mitochondrial health and function with age, and investigations of NAD+ depletion and the associated oxidative stress and damage corroborate these theories (1-2)

Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome

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These effects are mediated through downstream activation of transcription factors such as c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodeling, and angiogenic signaling [26]

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