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Athauda D., Maclagan K., Skene S

Physical and behavioral signs include taking doses larger than prescribed, using the medication without a prescription, crushing or snorting pills, strong cravings, and continuing use despite negative consequences at work, school, or in relationships

The pairing is studied so often precisely because the two compounds operate through distinct, complementary mechanisms rather than overlapping ones meaning a combined protocol covers more of the regenerative pathway landscape than either compound alone