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It has been shown to be effective in murine models of rheumatoid arthritis and may be beneficial in other chronic inflammatory diseases

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This mobile redox active arm can transfer electrons to the incoming oxidized Trx or internally to the Grx domain (C28/C31) of the partner subunit where reduction of oxidized glutathione (GSSG) occurs

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Importantly, the REW substitutions did neither affect thermal stability, aggregation, or the composition of N297-linked N -glycan structures (Fig