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Vedolizumab is licensed for both UC and CD for induction and maintenance therapy and is available as IV and SC formulations[86]

4.15 3D neuro-spheres imaging Cells were seeded per well in 100 L PrimNeuS media on a Nunclon Sphera 96-Well U-Shaped-Bottom Microplate (Thermo Scientific)

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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants

Once reconstituted, each vial must be used within 28 days