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Ruxolitinib, a JAK1/2 tyrosine kinase inhibitor approved for myelofibrosis, reverses GPX4 downregulation in TBI and mitigates neurodegeneration, cerebral edema, motor deficits, memory impairment, and anxiety-like behaviors (231)

When ROS levels in mitochondria are elevated due to electron leakage from the ETC, mitochondrial superoxide is generated, initiating a cascade of oxidative damage (90)

Antioxidant Protection: Helps fight free radicals and reduces early signs of aging

Reducing tissue damage and improving outcomes in ARDS may be achieved by inhibiting effector T cell ferroptosis

doi: 10.1631/jzus.B2300138

Proc West Pharmacol Soc 37: 5962