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Cytochrome c oxidase deficiency affects the brain, heart, and skeletal muscle, leading to disorders such as LS and cardiomyopathy (94)

[DOI] [PubMed] [Google Scholar] Noctor G, Mhamdi A, Chaouch S, Han Y, Neukermans J, Marquez-Garcia B, Queval G, Foyer CH

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Interestingly, hyperoxia enhances GPx-1 transcription in human umbilical-vein endothelial cells through a mechanism independent of the ORE (190), suggesting that GPx-1 transcription may be regulated in response to oxygen tension by more than one mechanism

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