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Intriguingly, characterization of the transcriptional response to cysteine deprivation has revealed glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) as the most highly induced gene 6

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However, there are also some examples where the reaction occurs spontaneously

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A.BraultC.PeckB.BensaadK.GriffithsB.MitterR.et al (2015)

10.1016/0003-9861(89)90600-0 Humphries DE, Silbert CK, Silbert JE: Sulphation by cultured cells
