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The possible mechanism underlying the increased oxidative stress might be mediated by complex I which is not only overexpressed in FTD3 neurons but also produces large amounts of superoxide when the matrix NADH/NAD + ratio is elevated as a result of increased TCA cycle activity (as also seen in diseased neurons)
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2H-J ), and behaves similarly to weak inhibitor W1, which is both salt- and concentration-insensitive ( Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Scholte B.J., Horati H., Veltman M., Vreeken R.J., Garratt L.W., Tiddens H.A., Janssens H.M., Stick S
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