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Prior to entering the nucleus, conjugation of the activated cisplatin with glutathione (GSH) by GSH S -transferases (GSTs) ( C ), or interaction with the sulfhydryl-containing metallothioneins ( D ) can result in reduced drug efficacy

[PubMed] [Google Scholar] 243.Franco P.G., Silvestroff L., Soto E.F., Pasquini J.M

Various new treatment options are being explored, such as the use of small molecules, apheresis therapy, enhancing gut microecology, cell therapy and exosome therapy (3,4)

Acta pathologica, microbiologica, et immunologica Scandinavica

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