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Mitochondrial dysfunction as a cause of ageing

This work develops the first mathematical model for the GSH antioxidant system in the outer retina, capturing the most essential components for formation of ROS, GSH production, its oxidation in detoxifying ROS, and subsequent reduction by NADPH

This data can be found here: 10.6084/m9.figshare.30110707

Conversely, when one of the components of iron uptake, storage, utilization and efflux is interfered [29], such as increased degradation of ferritin induced by nuclear receptor coactivator 4 (NCOA4) or inhibition of the iron export protein SLC40A1 [30, 31], intracellular iron homeostasis will be affected

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