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Due to the compounds plasma half-life of approximately 3.86.9 hours [5] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

Individuals with Gastrointestinal Disorders: Such as Crohns disease, celiac disease, atrophic gastritis, or those who have had gastric bypass surgery or other stomach/intestinal resections, which can interfere with B12 absorption

Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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Abstract Treatment with a nicotinamide N-methyltransferase inhibitor (NNMTi
