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Description

NRF2 can enter the nucleus and bind to the promoter with an antioxidant-response element (ARE, 5-TGACXXXGC-3) to turn on the expression of several antioxidant, detoxification enzymes and autophagy genes, including NADPH quinone dehydrogenase 1 ( NQO1 ), glutathione S-transferase ( GST ) genes and SQSTM1 [110, 112,113,114,115,116,117]

Epidemiology and Disease Control Division and Vector Borne Disease Research and Training Centre

[DOI] [PubMed] [Google Scholar] 108.Wilson JX, Peters CE, Sitar SM, Daoust P, Gelb AW

Collagen and fibroblast activity

Using luciferase reporter assays and DNA binding studies, they demonstrated that ATF4 directly binds to these elements, enhancing CHAC1 expression under ER stress conditions induced by chemicals like Thapsigargin and Tunicamycin