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Description
64 (3), e67e72
J Biol Chem 286(10):80758084
It's also present in breast milk, albeit in lower concentrations
Its canonical anti-inflammatory pathway contrasts with context-specific or biased signaling mechanisms that can contribute to either tumor suppression or promotion, highlighting the critical need to understand these nuances when considering TGR5 as a therapeutic target
A practical way to frame it is this
Deficiency of ATP-binding cassette transporters A1 and G1 in endothelial cells accelerates atherosclerosis in mice
