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J Neuroimmunol 2008

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A mouse model of CHS showed improved neutrophil chemotaxis following vitamin C supplementation [140], and neutrophils isolated from two children with CHS showed improved chemotaxis following supplementation with 200500 mg/day vitamin C [141,142], although this effect has not been observed in all cases [140,143]

CD44 was also reported to be upregulated in cholangiocytes associated with epithelial to mesenchymal transition 45 , in cholangiocarcinoma 46 and cholangiopathies 47 including in PSC patients 48,49

VEGF may also stimulate NRF-2-mediated antioxidant mechanisms (184)

6 Gene Ontology (GO) analysis of differentially expressed genes revealed enrichment of pathways related to neutrophil activation and inflammation, including innate immune response, regulation of inflammtory response and positive regulation of chemokine production (Fig